Tag Page Glioblastoma

This story is almost impossible to comprehend. Lori Coble, a California mother who once endured the unimaginable loss of three young children in a single car crash, is now facing another devastating chapter after being diagnosed with stage 4 glioblastoma, an aggressive form of brain cancer. After losing Kyle Christopher, Emma Lynn, and Katie Gene in a freeway accident, Lori and her husband made a promise to survive together and not let grief end their lives. In the midst of heartbreak, they chose hope — pursuing IVF and welcoming triplets just one year later. Each child carries the middle name of the sibling they lost, a living tribute to the children who never came home. Lori poured herself into motherhood again and became an advocate for highway safety, determined to protect other families from similar pain. Now, after stroke-like symptoms led to a shocking diagnosis, the family is once again facing uncertainty no parent should ever have to endure. People are calling her story one of resilience, faith, and heartbreaking strength — but it also raises a question that leaves many speechless: how much can one person be asked to carry in a lifetime? #HeartbreakingStory #FaithAndResilience #ChildLoss #IVFJourney #BrainCancerAwareness #Glioblastoma #StrengthInAdversity #LifeStories

🧠 The Vanishing Tumor: CAR T-Cell Therapy's Breakthrough! 🚀🔬 The astonishing result where a single dose of a new CAR T-cell therapy caused a patient's recurrent brain tumor to nearly disappear in just five days is True, originating from a groundbreaking early 2024 trial at Massachusetts General Hospital (MGH). 🤩 The Challenge of Glioblastoma (GBM) :- Glioblastoma (GBM) is one of the most aggressive and difficult-to-treat human cancers. Its complexity is due to several factors: Infiltration: GBM tumors quickly infiltrate brain tissue, making complete surgical removal impossible. Recurrence: It is highly recurrent and virtually always fatal, with a median survival of less than 15 months. The Blood-Brain Barrier (BBB): The BBB protects the brain, but it also prevents most traditional chemotherapy drugs from reaching the tumor effectively. The CARv3-TEAM-E Breakthrough :- Doctors at MGH used a brand-new, highly engineered type of CAR T-cell therapy called CARv3-TEAM-E. What is CAR T-Cell Therapy? It involves extracting a patient's own T-cells (immune cells), genetically re-engineering them in a lab to target specific cancer markers, and then infusing them back into the patient. They are essentially living drugs trained to hunt cancer. The Target: The CARv3-TEAM-E cells were engineered to target a specific protein called EGFRvIII found on the surface of glioblastoma cells. The Results: In the small initial trial, three patients with recurrent GBM were treated. One of the patients, diagnosed with a tumor the size of a plum, showed dramatic and rapid regression. The single dose, infused directly into the brain cavity, caused the tumor to shrink by 60% in a single day, and nearly vanish completely within five days. The patient remained recurrence-free for six months after the treatment. 💔 The Mechanism: This new variant of CAR T-cells is believed to be more effective because of the TEAM (T-cell engaging antibody molecule) component, which helps the T-cells overc